Puromycin dihydrochloride

CAS No.: 58-58-2

C22H29N7O5•HC1=544.43

Grade: ultra pure grade

Content: ≥ 98.0%

Melting point: 165 ~ 172 ℃

Solubility (5% water):pass

Product Description: protein synthesis inhibitor (causes premature chain termination by acting as an analysis of aminoacyl tRNA)

Physicochemical properties: white or off white powder

Purpose: biochemical research. The structure of antibiotics produced by Streptococcus furnishings fermentation is similar to the amino acid terminal structure connected with adenosine in amino acyl tRNA molecule. It can be used as an analog of amino acyl tRNA, so as to replace some amino acyl tRNA into ribosome a position and combine with the expanding polypeptide chain. When the extended peptide turns into this abnormal a position, it is easy to fall off, and the peptide purinomycin is formed to dissociate from ribosomes early, terminating peptide chain synthesis, This leads to the termination of protein synthesis and the release of immature peptides containing puromycin at the C-terminal. It is mainly used as a biochemical tool to study protein synthesis. Nucleotide antibody, protein synthesis inhibitor.

Storage: -20 ℃