Gefitinib / Iressa

CAS:184475-35-2        

Molecular formula: c22h24clfn4o3

Molecular weight: 446.90

Density: ~ 1.3 g / cm3

Loss on drying: ≤ 1.0%

Content: ≥ 99%

Physicochemical properties: white or off white powder, melting point 194 ℃ ~ 198 ℃. The pKas is between 5.4 and 7.2, and it will be gradually ionized as the pH value of the solution decreases. Gefitinib is almost insoluble in aqueous solution at pH = 7 and slightly soluble in aqueous solution at pH = 1; In non-aqueous solution, gefitinib is easily soluble in glacial acetic acid and dimethyl sulfoxide (DMSO); Soluble in pyridine; Partially dissolved in tetrahydrofuran; Slightly soluble in methanol, ethanol, ethyl acetate, isopropanol and acetonitrile.

Purpose: biochemical research, gefitinib is a selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, which is usually expressed in epithelial solid tumors. Gefitinib inhibits the growth and angiogenesis of human tumor cells xenografted in nude mice. In vitro, it can increase the apoptosis of human tumor cell derived lines and inhibit the invasion and secretion of angiogenic factors. Gefitinib has been proved in animal experiments or in vitro studies to improve the antitumor activity of chemotherapy, radiotherapy and hormone therapy.

Storage: 2 ~ 8 ℃, protected from light and moisture, sealed and dry.